Robbins Basic Pathology 10th Edition pdf free download

 Robbins Basic Pathology 10th Edition pdf free download.

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Acknowledgments:

Any large endeavor of this type cannot be completed without the help of many individuals. We thank the con- tributors of various chapters. Many are veterans of the older sibling of this text, the so-called "Big Robbins," and they are listed in the table of contents. To each of them, a special thanks. In addition, we are also very grateful to our clinical consultants for their input. They are listed separately after the contributor names. We are fortunate to continue our collaboration with Jim Perkins, whose illustrations bring abstract ideas to life and clarify difficult concepts, and we welcome members of our clinical advisory board who read various chapters for accuracy and appropriateness of the clinical content; they are listed on a separate page. Our assistants, Trinh Nu and Thelma Wright from Chicago, Ana Narvaez from San Francisco, and Muriel Goutas from Boston, deserve thanks for coordinating the tasks.

Many colleagues have enhanced the text by providing helpful critiques in their areas of interest. These include Dr. Rick Aster, who provided "late-breaking news" in the area of climate change science. Many others offered critiques of various chapters; they include Drs. Jerry Turner, Jeremy Segal, Nicole Cipriani, and Alex Gallan at the University of Chicago, Alex Gallan single handedly reviewed and updated over 100 clinical cases available online. Others have provided us with photographic gems from their per- sonal collections; they are individually acknowledged in the credits for their contribution(s). For any unintended omissions, we offer our apologies.

Many at Elsevier deserve recognition for their roles in the production of this book. This text was fortunate to be in the hands of Rebecca Gruliow (Director, Content Develop- ment), who has been our partner for several editions. Others deserving of our thanks are Bill Schmitt, Executive Content Strategist, who has been our friend and cheerleader for the past many editions. Upon his well-earned retirement. he handed over the charge to Jim Merritt, who had previ- ously worked on the immunology texts authored by one of us (AKA). Jim is a consummate professional and took over the "book" effortlessly. We are especially grateful to the entire production team, in particular Clay Broeker, Book Production Specialist, for tolerating our sometimes next to "impossible" demands and for putting up with our idiosyncrasies during the periods of extreme exhaustion that afflict all authors who undertake what seems like an endless task. We are thankful to the entire Elsevier team for sharing our passion for excellence, including Karen Giacomucci, Brian Salisbury, Tim Santner, Kristine McK- ercher, and Melissa Darling. We also thank numerous stu- dents and teachers scattered across the globe for raising questions about the clarity of content and serving as the ultimate "copyeditors." Their efforts reassured us that the

book is read seriously by them. Ventures such as this exact a heavy toll from the fami- lies of the authors. We thank them for their tolerance of our absences, both physical and emotional. We are blessed and strengthened by their unconditional support and love and by their sharing with us the belief that our efforts are worthwhile and useful. We are especially grateful to our wives Raminder Kumar, Ann Abbas, and Erin Malone, who continue to provide steadfast support.

And finally, we the editors salute each other; our part- nership thrives because of a shared vision of excellence in teaching despite differences in opinions and individual styles.

Preface:

The tenth edition is an important milestone in the life of a text- hook. This occasion is a propitious time to look back on the origins of Basic Pathology, which are summed up best by quoting Stanley Robbins from the preface of the first edition (1971):

"Of books as well as men, it may be observed that fat ones contain thin ones struggling to get out. In a sense, this book bears such a relationship to its more substantial progenitor, Robbins Pathology. It arose from an appreciation of the modern medical student's dilemma. As the curricu- lum has become restructured to place greater emphasis on clinical experience, time for reading is correspondingly curtailed....In writing this book, rare and esoteric lesions up to date. are omitted without apology, and infrequent or trivial ones described only briefly. We felt it important, however, to consider rather fully the major disease entities."

While the goals of "baby Robbins" remain true to the vision of Stanley Robbins, this edition has been revised on the basis of a few additional principles.

First, it is obvious that an understanding of disease mechanisms is based more than ever on a strong foun- dation of basic science. In keeping with this, we have always woven the relevant basic cell and molecular biology into the sections on pathophysiology in various chapters. In this edition we go one step further and intro- duce a new chapter titled "The Cell as a Unit of Health and Disease" at the very beginning of the book. In this chapter we have attempted to encapsulate aspects of cell and molecular biology that we believe are helpful in prepar- ing readers for discussions of specific diseases. It is, in essence, a refresher course in cell biology.

Second, as teachers, we are acutely aware that medical students feel overwhelmed by the rapid growth of infor- mation about the molecular basis of disease. We have therefore excluded those new "breakthroughs" in the laboratory that have not yet reached the bedside. Thus, for example, the drugs developed for targeting cancer mutations that are still in clinical trials have not been discussed except in those rare instances in which the evidence of efficacy is close to hand. Similarly, in geneti- cally heterogeneous disorders, we have focused on the most common mutations without providing a catalog of all the genes and polymorphisms involved. Thus, we have tried to balance discussions of advancement in sciences with the needs of students in the early stages of their careers. This effort required us to read each chapter as if it was written de novo and in many cases to remove parts of the text that had been present in the previous edition. It is our hope that these changes will unburden the students and that the tenth edition will be seen as an up to date yet simple to comprehend book.

Third, because illustrations facilitate the understanding of difficult concepts such as control of the cell cycle and the actions of cancer genes, the art has been significantly revised and enhanced by adding depth so that the four-

color figures are seen in three dimensions. Finally, we have added a board of clinical consultants to help us in keeping the clinical content accurate and

As an additional "tool" to help students focus on the fundamentals, we have continued the use of Summary boxes designed to provide key "take home" messages. These have been retained at the risk of adding a few addi- tional pages to the book because students have uniformly told us that they find them useful.

Although we have entered the genomic era, the time- honored tools of gross and microscopic analysis remain useful, and morphologic changes are highlighted for ready reference. The strong emphasis on clinicopathologic cor- relations is maintained, and, wherever understood, the impact of molecular pathology on the practice of medicine is emphasized. We are pleased that all of this was accom- plished without a significant "bulge" in the waistline of the text.

We continue to firmly believe that clarity of writing and proper use of language enhance comprehension and facili- tate the learning process. Those familiar with the previous editions will notice significant reorganization of the text in many chapters to improve the flow of information and make it more logical. We are now in the digital age, so the text will be available online. In addition, over 100 updated and revised cases developed by one of us (VK) will also be available, linked to the electronic version of the text. We hope that these interactive cases will enhance and reinforce learning of pathology through application to clinical cases.

It is a privilege for us to edit this book, and we realize the considerable trust placed in us by students and teachers of pathology. We remain acutely conscious of this respon- sibility and hope that this edition will be worthy of and possibly enhance the tradition of its forebears.

About The Authors:

Vinay Kumar, MBBS, MD, FRCPath

Alice Hogge and Arthur A. Baer Distinguished Service Professor of Pathology Biological Sciences Division and The Pritzker Medical School

University of Chicago Chicago, Illinois

Abul K. Abbas, MBBS

Department of Pathology

Distinguished Professor and Chair University of California, San Francisco San Francisco, California

Jon C.Aster, MD, PhD

Professor of Pathology

Brigham and Women's Hospital and Harvard Medical School Boston, Massachusetts