Insulin NPH/Bovine Insulin, Overview, Indications, Contraindications, Side effects, Warnings and High Risk Group

Insulin NPH/Bovine Insulin, Overview, Indications, Contraindications, Side effects, Warnings and High Risk Group 

Overview:

Insulin is a hormone produced by the beta cells of the islets of langerhans of the pancres and consists of 2 chains of aminoacids. It contains 51 amino acid arranged in two chains (A and B) joined together by disulfide linkage. In 1921, Banting and Best extracted insulin from the pancrease and demonstrated its therapeutic effects in diabetic dogs and human subjects.

Indications:

Bovine Insulin is primarily indicated in conditions like Diabetes mellitus, Hyperkalaemia.

Contraindication:

Bovine Insulin is contraindicated in conditions like Hypersensitivity.

Side effect:

Bovine Insulin produces potentially life-threatening effects which include Hypoglycemia. which are responsible for the discontinuation of Bovine Insulin therapy. The symptomatic adverse reactions produced by Bovine Insulin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Allergy, Lipoatrophy, Antibody formation.

Warnings:

It should be used with caution in case of bovine hypersensitivity, breast feeding, coma, diarrhea, fever, infections, porcine hypersensitivity, renal inpairment, surgery, thyroid disease, trauma, and vomiting.

High Risk Group:

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.