MYASTHENIA GRAVIS:

-Myasthenia Gravis is long term neuromuscular disease that leads to varying degree of muscle weakness.

PATHOPHYSIOLOGY:

It is autoimmune synaptopathy, autoantibodies against nicotinic acetylcholine receptor on muscle endplate cause nerve conduction block resulting in muscle weakness.

CLINICAL FEATURES:

Ptosis

Diplopia

Muscle weakness

Trouble talking, trouble walking,

Respiratory muscle weakness (can cause death)

INVESTIGATION:

Blood test: Anti-MUSK & Anti-Ach Receptor Antibodies
Nerve conduction studies

MANAGEMENT:

Medication: Neostigmine, Pyridostigmine, Prednisone

Immunology: IVIG, Plasmapheresis

Surgery: Remove Thymus gland