Sunday, April 6, 2025

Amoxicillin

 Amoxicillin 

Overview:

Amoxicillin is oral semisynthetic aminopenicillin similar to ampicillin. Amoxicillin is more stable to gastric acids and more bioavailable than other penicillin. It inhibits the 3rd and final stage of bacterial cell wall synthesis by binding to specific penicillin-binding proteins PBPs that are located inside the bacterial cell wall and are responsible for several steps in the synthesis of the cell wall.

Chemically Amoxicillin is D-(-)-a-amino-p-hydroxy- benzyl penicillin. Amoxicillin is a broad spectrum antibiotic and has bactericidal activity against many gram positive and gram negative bacteria. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular intervals of time throughout the day and night as prescribed. Amoxicillin is important to take the drug for the full time period as prescribed. If you discontinue the drug it may result in ineffective treatment.



Indications:

Amoxicillin is primarily indicated in conditions like Abscesses, Acute bronchitis, Bacteriuria, Bronchitis, Carbuncles, Cellulitis, Chronic bronchitis, Cystitis, Dental abscess, Dental abscess (short-course), Endocarditis, Furunculosis, Gonorrhoea, Gynecological infections, Haemophilus influenzae infections, Helicobacter pylori eradication, Infected wounds, Inflammatory bowel disease, Lower respiratory tract infections, Meningitis, Metastatic, Metastatic colorectal cancer, Mild to moderate chronic heart failure, Muscle relaxation (short duration) for surgery, Muscle relaxation during intensive care, Muscle relaxation for surgery or intubation, Osteomyelitis, Otitis media, Parathyroid fever, Peritonitis, Pharyngitis, Pneumonia, Puerperal sepsis, Pyelonephritis, Septic abortion, Septicaemia, Sinusitis, Skin infections, Soft tissue infections, Surgical infections, Syphilis, Systemic infections, Tonsillitis, Typhoid, Urinary tract infection.

Contraindications:

Amoxicillin is contraindicated in conditions like Lymphoma, Glandular fever, Documented hypersensitivity to penicillin, cephalosporins, imipenem.

Side effects:

The severe or irreversible adverse effects of Amoxicillin, which give rise to further complications include Pseudomembranous colitis, Thrombocytopenia, Stevens johnson syndrome, Nephrotic syndrome, Eosinophilia, Leucopenia, Neutropenia, Seizures, Agranulocytosis, Interstitial nephritis, Hemolysis, Platelet dysfunction.Amoxicillin produces potentially life-threatening effects which include Anaphylactic shock. which are responsible for the discontinuation of Amoxicillin therapy. The signs and symptoms that are produced after the acute overdosage of Amoxicillin include Crystalluria, Hemorrhagic cystitis. The symptomatic adverse reactions produced by Amoxicillin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Anorexia, Diarrhea, Fever, Abdominal pain, Maculopapular rash, Rashes, Gastritis, Indigestion, Urticarial skin rash, Pseudomembranous colitis, Elevation of liver enzymes, Nausea and vomiting, Cholestatic Jaundice, Hepatitis, Bullous rash, Arrhythmia.

Warnings:

Amoxicillin should be used with caution in patients with medical history especially kidney disease, stomach or intestinal problems, blood disorders or drug allergies, especially allergies to other penicillin or cephalosporin antibiotics. Do not use amoxicillin repeatedly or for prolonged period, because use of this medication for prolonged or repeated periods may result in a secondary infection (e.g.oral, bladder or vaginal yeast infection). Use with extreme caution during pregnancy or lactation.

Dosage:

Adults:

Dose                     0.25 to 0.5 g

Single Dose         0.38 (0.375)

Frequency           8 hourly

Route.                  PO, IV, IM

Instructions

Doses vary according to indication. In typhoid fever and Meningitis, 150 mg/Kg/day in adults and 100-150 mg/kg/day in children should be given. Doses greater than 500 mg is given in divided doses.

Peadiatric:

Route.                 Oral

Dose.                  20 to 40 mg/kg
  
Single Dose.       30 (30)

Frequency.          8 hourly



Route.                Inra Muscular

Dose.                 50 to 100 mg/kg

Single Dose.      75 (75)

Frequency.         6 hourly



Route.                 Intra Venous

Dose.                 50 to 100 mg/kg

Single Dose.      75 (75)

Frequency.         6 hourly 

Wednesday, May 8, 2024

MYASTHENIA GRAVIS

MYASTHENIA GRAVIS:

-Myasthenia Gravis is long term neuromuscular disease that leads to varying degree of muscle weakness.

PATHOPHYSIOLOGY:

It is autoimmune synaptopathy, autoantibodies against nicotinic acetylcholine receptor on muscle endplate cause nerve conduction block resulting in muscle weakness.

CLINICAL FEATURES:

Ptosis

Diplopia

Muscle weakness

Trouble talking, trouble walking,

Respiratory muscle weakness (can cause death)

INVESTIGATION:

Blood test: Anti-MUSK & Anti-Ach Receptor Antibodies
Nerve conduction studies

MANAGEMENT:

Medication: Neostigmine, Pyridostigmine, Prednisone

Immunology: IVIG, Plasmapheresis

Surgery: Remove Thymus gland

Saturday, January 27, 2024

Insulin NPH/Bovine Insulin, Overview, Indications, Contraindications, Side effects, Warnings and High Risk Group

Insulin NPH/Bovine Insulin, Overview, Indications, Contraindications, Side effects, Warnings and High Risk Group 

Overview:

Insulin is a hormone produced by the beta cells of the islets of langerhans of the pancres and consists of 2 chains of aminoacids. It contains 51 amino acid arranged in two chains (A and B) joined together by disulfide linkage. In 1921, Banting and Best extracted insulin from the pancrease and demonstrated its therapeutic effects in diabetic dogs and human subjects.



Indications:

Bovine Insulin is primarily indicated in conditions like Diabetes mellitus, Hyperkalaemia.

Contraindication:

Bovine Insulin is contraindicated in conditions like Hypersensitivity.

Side effect:

Bovine Insulin produces potentially life-threatening effects which include Hypoglycemia. which are responsible for the discontinuation of Bovine Insulin therapy. The symptomatic adverse reactions produced by Bovine Insulin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Allergy, Lipoatrophy, Antibody formation.

Warnings:

It should be used with caution in case of bovine hypersensitivity, breast feeding, coma, diarrhea, fever, infections, porcine hypersensitivity, renal inpairment, surgery, thyroid disease, trauma, and vomiting.

High Risk Group:

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Metformin, Overview, Indications, Contraindications, Side effects, Warnings, High Risk Group

 Metformin, Overview, Indications, Contraindications, Side effects, Warnings, High Risk Group

Overview:

Metformin (HCI) is oral biguanide antidiabetic agent, introduced in 1950s. It reduces elevated blood glucose concentration in diabetic patients, but it does not increase insulin secretion. Metformin (HCI) is used alone or in combination with insulin or chlorpropamide. Most useful in overweight subjects, where it supresses appetite. May cause nausea, vomiting and diarrhoea.



Indications:

Metformin (HCI) is primarily indicated in conditions like Diabetes mellitus, Hyperlipoproteinaemia, Insulin dependent diabetes mellitus, Insulin resistance, Non-insulin dependent diabetes mellitus, Obesity.

Contraindication:

Metformin (HCI) is contraindicated in conditions like Alcohol dependence, Anaemia, Myocardial infarction, Septicaemia, Infections, Respiratory disease, Ketosis, Cardiovascular disease, Diabetic coma, Trauma, Liver damage, Iron deficiency, Vitamin B12 deficiency, Renal impairment, Diabetic retinopathy.

Side Effects:

The severe or irreversible adverse effects of Metformin (HCI), which give rise to further complications include Vasculitis, Pneumonitis, Malabsorption of vit B12, Malabsorpton of folic acid, Megaloblastic anemia, Hypoglycemia. Metformin (HCI) produces potentially life-threatening effects which include Lactic Acidosis. which are responsible for the discontinuation of Metformin (HCI) therapy. The symptomatic adverse reactions produced by Metformin (HCI) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Abdominal distension, Flatulence, Nausea, Vomiting, Anorexia, Diarrhea, Skin reactions, Weight LossX, Hypersensitivity, Metallic taste.

Warnings:

Metformin should be used with caution in patients with pre-existing liver disease, kidney disease, heart trouble or if have any allergy, infections. Avoid excessive use of alcohol while taking this. It is not recommended for use during pregnancy and should be used only if clearly needed during lactation.

High Risk Groups:

Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Wednesday, November 15, 2023

Aspirin, Overview, Indications, Contraindications & Side effects

Aspirin, Overview, Indications, Contraindications & Side effects  

Overview:

Aspirin is an NSAID (non-steroidal anti-inflammatory drug). It has anti-infalammatory, analgesic, antipyretic and antithrombotic activity. It interferes with prostaglandin synthesis by irreversibly inhibiting cyclooxygenase. It was synthesized in 1853, but the drug was not in use until 1899, when it was found to be effective in the arthritis and well tolerated. The name it was coined from the German word for the compound, acetylspirsaure. Because of its greater efficacy and lower cost, it rapidly replaced the natural products in use at that time, and has remained one the most widely employed remedies for over 90 years.

Indications:

Aspirin is primarily indicated in conditions like Fever, Following coronary bypass surgery, Headache, Inflammation, Ischaemic event (unstable angina, myocardial infarction), Mild to moderate pain, Myocardial infarction, Myocardial infarction prophylaxis, Pain and inflammation (in rheumatic disease, in other musculoskeletal disorders), Prophylaxis of cerebrovascular disease, Pyrexia, Stable angina, Stable angina pectoris, Stroke prophylaxis, and can also be given in adjunctive therapy as an alternative drug of choice in Arterial thromboembolism prophylaxis, Colorectal carcinoma prophylaxis, Juvenile rheumatoid arthritis, Neurogenic bladder, Osteoarthritis.

Contraindications:

Aspirin is contraindicated in conditions like Gl ulceration, Hypoprothrombinemia, Hypersensitivity.

Side Effects:

The severe or irreversible adverse effects of Aspirin, which give rise to further complications include Urticaria, Gi bleeding, Rhinitis, Angioneurotic edema, Hepatitis, Hepatomegaly.Aspirin produces potentially life-threatening effects which include Cerebral hemorrhage, Airway obstruction, Gastric ulceration, Gastric erosion. which are responsible for the discontinuation of Aspirin therapy.The signs and symptoms that are produced after the acute overdosage of Aspirin include Coma, Acidosis, Hyperthermia, Volume depletion, Hyperglycemia, Renal failure, Hyperventilation, Cardiovascular collapse, Vertigo, Tinnitus, Hyperkalemia.The symptomatic adverse reactions produced by Aspirin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Vertigo, Nausea, Vomiting, Tinnitus, Epigastric discomfort, Dyspepsia, Asthma, Respiratory alkalosis, Bleeding.

Warnings:

Aspirin should be used with caution in patients with chronic renal insufficiency, gastric ulcer, severe anemia, and patients intolerant to salicylate. Avoid aspirin in patient with history of blood coagulation defects and if patient taking anticoagulants. Liver function should be monitored in patients receiving large doses of aspirin or in patients with pre-existing hepatic disease in order to prevent reversible, dose dependent hepatotoxicity.

High Risk Groups:

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Pregnancy:

Avoid chronic or intermittent high doses during pregnancy; may affect maternal and newborn hemostasis mechanisms, leading to an increased risk of hemorrhage.

Premature closure of the ductus arteriosus may occur if used near term with use of full-dose aspirin.


Acetaminophen, Paracetamol, Overview, Indications, Contraindications & Side effects

 Acetaminophen, Paracetamol, Overview, Indications, Contraindications & Side effects 

Overview:

Paracetamol is analgesic and antipyretic agent. Paracetamol is the active metabolite of phenacetin, responsible for its analgesic effect. Paracetamol is a weak prostaglandin inhibitor in peripheral tissues and possesses no significant antinflammatory effects. Paracetamol is one of the most important drug used for the treatment of mild to moderate pain when an antinfalmmatory effect is not necessary. Paracetamol is preferred over aspirin as an analgesic/antipyretic for patients in whom aspirin is contraindicated, such as those who have a history of gastric ulcer or a coagulation disorder.

Indications:

Paracetamol is primarily indicated in conditions like Ear pain, Fever, Headache, Malaise, Migraine, Mild to moderate pain, Pain, Post-vaccine reaction, Short-bowel syndrome, Tobacco amblyopia and leber's optic atrophy, Toothache.

Contraindication:

Paracetamol is contraindicated in conditions like Hypersensitivity.

Side Effects:

The severe or irreversible adverse effects of Paracetamol, which give rise to further complications include Bronchospasm.Paracetamol produces potentially life-threatening effects which include Blood dyscrasias, Centribular Necrosis, Liver damage. which are responsible for the discontinuation of Paracetamol therapy. The signs and symptoms that are produced after the acute overdosage of Paracetamol include hypoglycemic coma, Hepatic necrosis, Liver failure, renal tubular necrosis.The symptomatic adverse reactions produced by Paracetamol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Skin rashes, Gl adverse effects.

Warnings:

If sensitivity reaction occurs, discontinue use of paracetamol. If pain persist more than 10 days and arthritic and rheumatic condition affecting children, immediately consult physician. If patient have been diagnosed with liver or kidney impairment, seek medical advice before taking medication. If symptoms persists consult doctor.

Pregnancy:

Drug crosses placenta and can be detected in cord blood, newborn serum, and urine immediately after delivery.
Increased risk of teratogenic effects not reported.
Use of normal doses during pregnancy not associated with increased risk of miscarriage or still birth; however, increase in fetal death or spontaneous abortion may be seen with maternal overdose if treatment delayed.


Sunday, November 12, 2023

Oral Infection

 Oral Infection:

Overview:

Infection involving the oral cavity can be associated with significant morbidity. In addition, recent studies have suggested that some types of oral infection may potentially confound a number of systemic problems including cardiac disease, pregnancy, kidney disease, and diabetes. 

Relevant anatomy:

The oral cavity (see the image below) is oval shaped and is separated into the oral vestibule and the oral cavity proper. It is bound by the lips anteriorly, the cheeks laterally, the floor of the mouth inferiorly, the oropharynx posteriorly, and the palate superiorly. The oropharynx begins superiorly at the junction between the hard palate and the soft palate, and inferiorly behind the circumvallate papillae of the tongue. The bony base of the oral cavity is represented by the maxillary and mandibular bones.

The tongue is basically a mass of muscle that is almost completely covered by a mucous membrane. It occupies most of the oral cavity and oropharynx. It is known for its role in taste, but it also assists with mastication (chewing), deglutition (swallowing), articulation (speech), and oral cleaning. Five cranial nerves contribute to the complex innervation of this multifunctional organ.

Microbiology of Oral Infection:

Oral bacteria are diverse, but in the immunocompetent individual the interaction between the various complex competing microflora provides relative stability. The different structures and anatomy within the mouth afford various microenvironments that support different types of microbiologic organisms. In the first few years of life, the bacterial microbiota within the mouth is predominantly aerobic, but, as the teeth develop, favorable sites supporting pathogenic anaerobic bacteria emerge.

Biofilm, on teeth termed plaque, can build up in the mouth and reach substantial numbers. It has been estimated to reach up to 1011 microorganisms/mL in plaque that is not removed over several days. Apical periodontal infection has been associated with 200 bacterial species, and 500 bacterial species have been reported with marginal periodontitis. Evidence also exists that significant interaction of bacterial types within biofilm may either enhance or suppress metabolic activity that leads to dental infection.

Factors that regulate the number of oral bacteria include general exposure, saliva, diet, bacterial retention, bacterial interaction, the complexity of the flora, native resistance, and hygiene. Change in the condition of any one of the above factors or combination thereof can result in oral hard or soft tissue infection.

For example, a diet rich in dietary carbohydrate such as refined sugar favors bacteria such as Streptococcus mutans, the organism that causes dental caries. The consistency of the diet is also important in that courser foods eliminate particles that can sustain microorganisms. Specificity in terms of bacteria tissue adherence also appears to exist; for example, S mutans and Streptococcus sanguis typically adhere to hard surfaces, while Streptococcus salivarius is found primarily on the tongue.

A number of systemic diseases can reduce host defense mechanisms, leading to reductions in phagocytic activity, pulmonary clearance, and circulation, with these factors contributing to oral infection. They include malnutrition, alcoholism, diabetes, cystic fibrosis, renal failure, lymphoproliferative disorders, heart failure, and chronic lung disease.

Immunosuppressants and other medications used as cytotoxic chemotherapeutic agents, including steroids, can reduce host defense mechanisms leading to infection. Antibiotic medication can also alter the oral microbial environment leading to oral infection. For example, prolonged antibiotic therapy can reduce the normal bacterial flora, resulting in the selection of resistant flora and/or the emergence of competing fungal organisms. Other factors potentially confounding the possibility of oral infection include age, potential drug abuse, family and social environment, and the patient’s psychological status.

Oral infection can also be caused by viral and fungal organisms. Common viral infections include herpes simplex (primary and secondary recurrent herpes infection), varicella zoster (shingles), and coxsackievirus. The presence of the papilloma virus is considered an infection and has assumed importance in that it has been linked to the development of oral squamous cell carcinomas.

Viral and Fungal Oral Infection:

As mentioned previously, oral infection can also be caused by viral (eg, herpes simplex [primary and secondary recurrent herpes infection], varicella zoster [shingles], coxsackievirus) and fungal organisms. The presence of the papilloma virus (see image below) is considered an infection and has assumed importance in that it has been linked to the development of oral squamous cell carcinomas. 


Primary viral infections involving the oral mucosa are covered elsewhere. However, a condition not typically described in the literature is intraoral recurrent herpes (see image below). This infectious process is the equivalent of the secondary recurrent lesion of herpes but occurs on the attached gingival tissue adjacent to the teeth, including the palate, rather than the lip. A prodromal phase often exists in which the tissue feels itchy or tingles. This dysesthesia is then followed by the development of multiple small punctuate ulcers that coalesce and are painful. The infection may last 10-14 days and reoccur in response to stress, fever, trauma, and hormonal alterations. No good evidence exists that sunlight activates the latent virus, as occurs with the secondary lip lesion.


The most common oral mycotic infection is candidiasis, but other infections such as mucormycosis (phycomycosis), actinomycosis (see image below), aspergillosis, and pneumocystosis can occur under the right circumstances. Candida is an opportunistic organism and does not typically cause infection unless other host factors are compromised. Systemic conditions that can contribute to candidiasis include xerostomia, diabetes mellitus, and immune system suppression (eg, HIV infection or as a side effect of drying medications). Candidiasis can also result from poorly fitting prosthetic oral appliances and poor oral hygiene.

The most common oral mycotic infection is candidiasis, but other infections such as mucormycosis (phycomycosis), actinomycosis (see image below), aspergillosis, and pneumocystosis can occur under the right circumstances. Candida is an opportunistic organism and does not typically cause infection unless other host factors are compromised. Systemic conditions that can contribute to candidiasis include xerostomia, diabetes mellitus, and immune system suppression (eg, HIV infection or as a side effect of drying medications). Candidiasis can also result from poorly fitting prosthetic oral appliances and poor oral hygiene.

Candidiasis can occur in 3 forms: pseudomembranous, atrophic/erythematous, and chronic/hyperplastic. The first form, pseudomembranous, is characterized by multiple soft, white, slightly elevated plaques that can be wiped away, leaving an erythematous and bleeding surface (see image below). The second form is characterized by erythematous tissue that is sensitive to touch, and the third by confluent slightly raised white areas. Culturing for candida is useful in cases in which the diagnosis is unclear. 

Caries and Periapical Infection:

Caries are the most common odontogenic infection. Prevalence appears to vary depending on the region of the world surveyed. When dental infection is limited to the enamel and dentine of the tooth, it does not present a severe problem. A carious process that extends into the dental pulp chamber and the neural, vascular, and connective tissue contained within presents a more serious matter.

The bacteria that reach the pulp are mostly anaerobic and host resistance is limited by the constricted anatomy of the tooth pulpal chamber. Once the pulp has become involved, the inflammation and edema associated with the carious infection causes a vascular necrosis and the death of this tissue. This process then generally results in the infection spreading beyond the apex of the root (ie, the periapical region).

Osteomyelitis and Cellulitis:

Once the infectious process has extended beyond the tooth, it may expand into the surrounding medullary bone and cause an osteomyelitis, or it may extend focally through the bone as a fistular tract draining into the oral cavity. The latter condition drains the infection, reduces general swelling, and results in a small soft tissue swelling and focal erythema at the site of the mucosal involvement.

However, a periapical infection may also evolve into a localized soft tissue abscess or a more diffuse and troublesome soft tissue cellulitis. The spread of infection into fascial spaces can be problematic for the patient and treating clinician. A cellulitis can involve incorporation of adjacent spaces and inferior (eg, neck and mediastinal region) and superior (eg, base of the skull, foramen ovale, and brain — cavernous sinus thrombosis) extension.

The relative risk of fascial space infection is related to the location of the space in relation to the anatomy of the head and neck. Low-risk anatomical areas include the region of the facial vestibule of the mandible, the body of the mandible, the buccal vestibule of the mandible, and the palate. Moderate risk areas include the mentalis space, submental space, sublingual space, submandibular space, buccal space, submasseteric space, superficial and deep temporal space, and the maxillary sinus. The highest-risk regions include the infratemporal and parotid spaces; the pterygomandibular, parapharyngeal, and peritonsillar spaces; and the cervical, infraorbital, periorbital region, and the base of the lower lip. Infection that has spread to these latter areas must be treated aggressively.

Signs and symptoms for the various space infections vary. For example, infection of the sublingual space itself is not evident by external examination. However, the patient feels like the tongue has been pushed up, and difficulty swallowing can exist. In contrast, Ludwig angina, which represents a more extensive involvement, not only of the sublingual space but space below the mandible, severely displaces the tongue upwards and backwards. Extensive swelling of the anterior neck extending down to the clavicles may become evident. With extension of the infection, the patient is febrile and breathing is often labored. Obstruction of the throat due to edema of the glottis causes further deterioration.

Other commonly observed general signs of cellulitis include jaw-opening limitation (eg, trismus), and distension of the involved region (eg, the lip, cheek), and bulging of muscle (eg, the temporalis). In cases of parotid space infection, suppuration from the parotid duct may be present. Typically, pain is described as throbbing and severe tenderness to palpation exists. Pain worsens often quickly over time and is not controlled by nonprescription medication.

Osteomyelitis can follow chronic odontogenic infection not involving cellulites. The incidence of the disease has decreased with the advent of antibiotics, caries prevention, and restorative dentistry. However, chronic diseases, immune deficiency, and vascular abnormality may predispose an individual to the infection.

The course of osteomyelitis can include suppuration with abscess or fistula formation and jaw bone sequestration. Acute osteomyelitis is associated with the classical features of infection including fever, leukocytosis, lymphadenopathy, pain, and soft tissue swelling. If the condition involves the lower jaw there may be lip dysesthesia or paresthesia. Chronic osteomyelitis may also involve purulent discharge, tooth loss, or pathologic fracture. The condition typically involves symptom remission and recrudescence. Note that osteomyelitis can result from local or metastatic neoplasm as well as jaw bone fracture.

Diffuse sclerosing osteomyelitis is a variation of osteomyelitis, but it involves fairly focal areas of chronic infection that can cause periosteal and cortical bulging in adults (typically) without frank sequestration of the cortex. However, internal sequestration occurs. Low-grade persistent pain exists. Condensing osteitis is the name of the condition involving bone sclerosis associated with long-standing pulpitis or pulpal necrosis without demonstrative infection. Infection associated with removal of a tooth is termed alveolar osteitis or dry socket. Another newly defined condition involving infection of implants from adjacent dental infection is termed retrograde periimplantitis.

Periodontal Disease:

The most common oral mucosal infection is periodontal disease. This condition is considered a major public health problem in many countries.  Periodontitis has been associated with the proliferation of the bacteria Actinobacillus actinomycetemcomitans,Porphyromonas gingivalis, and Prevotella intermedia. Infection involves the supporting structures of the teeth and causes progressive loss of gingival attachment with absorption of supporting alveolar bone. This results in periodontal pocket formation, which can lead to further disease including tooth loss. When a deep periodontal pocket closes along the superior interface with a tooth trapping bacteria, this condition can lead to abscess.

Several forms of periodontal infection are described. They include aggressive periodontitis, which occurs in otherwise healthy individuals but causes rapid bone loss; chronic periodontitis characterized by gingival pocket formation and bone loss occurring over a prolonged period of time; periodontitis as a manifestation of systemic disease; and necrotizing periodontal disease, which involves severe necrosis of the gingival tissue. This condition is most often associated with the presence of systemic conditions such as HIV infection, malnutrition, and immunosuppression.

Known contributory factors to periodontal infection include age, plaque and calculus, smoking, diabetes mellitus, general health status, and social economic level. Low bone density of osteoporosis appears to be a shared risk factor for periodontitis rather than a causal factor. A study by Teeuw et al on 313 dental patients found that suspected new diabetes was found in 18.1% of patients diagnosed with severe periodontitis (78 patients) compared to 9.9% and 8.5% in patients with mild or moderate periodontitis and the control group.

Periodontitis is preceded by infection and inflammation of the attached gingival adjacent to teeth. This is termed gingivitis. Both gingivitis as well as periodontitis may be asymptomatic unless a frank abscess exists. Symptoms of gingivitis and periodontitis include foul breath and gingival tenderness with palpation; signs can include gingival bleeding, tooth mobility, and gingival erythema and swelling. 
Moderate chronic gingivitis. Note that the papillae are edematous and blunted. They may bleed with brushing. Note areas of edema overlying some of the root areas. Pallor is seen in these areas.

Severe periodontal disease. Loss of the gingival tissue is seen, making the teeth appear long. Even more effacement of the papillae is present. Heaped up ridges are observed in the areas overlying the roots.


Minor Salivary Gland Infection:


Infection involving the intraoral minor salivary glands is relatively rare. However, minor gland infection can follow sialolithiasis. This condition begins with the formation of a small calculi or stone that blocks the duct of the minor gland. A secondary infection may then ensue. Sialadenitis can also follow viral infection and can be associated with neoplastic activity. The condition typically causes erythema and swelling of the minor gland duct. Minor glands are located throughout the mouth but most frequently in the cheek, lip, and palatal region. Major salivary gland infection including acute and chronic bacterial parotitis, viral parotitis (ie, mumps), and other conditions causing salivary gland infection such as tuberculosis and parotid or submandibular actinomycosis is covered elsewhere.














Amoxicillin

 Amoxicillin  Overview: Amoxicillin is oral semisynthetic aminopenicillin similar to ampicillin. Amoxicillin is more stable to gastric acids...